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Higher similarity in the abstract, introduction, materials and methods, and discussion and conclusion sections indicates that the manuscript may contain plagiarized text. Authors can easily explain these parts of the manuscript in many ways.
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Bentham Open has collaborated with Focus Medica, a reputable publisher of expert animated atlases and videos in medicine and science, to create the animated abstracts. Each professionally produced full-coloured animated abstract in video format length 3 — 5 minutes is accompanied by a commentary in English. Please complete and sign the Credit Card Authorization and attach it to your passport application.
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My Service Canada Account. In our previous study on human rRNA genes Chen et al. Although our preliminary experiments supported the existence of RNAi, the identity of the enzyme that caused bp duplexes in U1 snRNAs remains unclear. The ancestral function of RNAi is generally agreed to have been immune defense against exogenous genetic elements such as transposons and viral genomes Buchon and Vaury, Mature RNAs containing a greater number of hairpin structures have more chances to induce RNAi, which is important for highly expressed genes e.
As DNA complemented palindromes are prone to produce dsRNA regions, viruses containing a greater number of such DNA complemented palindromes in their genomes have more chances to induce RNAi for the regulation of gene expression, which is important for their infectivity and pathogenesis. In the past 20 years, research on U1 snRNA has focused on its primary function, particularly as it relates to neurodegenerative diseases caused by abnormalities in U1 snRNA Cheng et al.
This finding helped better understanding of neurodegenerative diseases caused by abnormalities in U1 snRNA.
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We also provided a novel view on cancer and virus-induced diseases. In one of our previous studies, we reported that U1 snRNA over-expression affected the expression of mammal genes on a genome-wide scale and that U1 snRNA could regulate cancer gene expression. This was explained by the fact that alternative splicing AS and alternative polyadenylation APA were deregulated and exploited by cancer cells to promote their growth and survival Spraggon and Cartegni, One perl script Supplementary Table S1 was used to transform Pileup files into 5-end files.
Statistical computation and plotting were performed using the software R v2. Each group contained three samples for biological replicates and the control samples used unprocessed cells. Their accession numbers are provided in the method section.
Author Contributions SG conceived the project and drafted the main manuscript. SG and ZeC supervised this project.
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JR and WB revised the manuscript. All authors have read and approved the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments We appreciate the help equally from the people listed below.
References Bouvy-Liivrand, M. Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture.Their accession numbers are provided in the method section.
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